Company History

As a research-focused company, BioCell Technology has made key benchmarks throughout its history. BioCell Collagen™ is our flagship dietary ingredient which has received multiple US and international patents for its innovation of hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II in various ingestible and topical applications, including but not limited to, methods of replenishing hyaluronic acid and chondroitin sulfate, restoring skin viscoelasticity, retaining skin moisture, and inducing cartilage formation. BioCell Collagen is substantiated by multiple human clinical trials for safety and efficacy the outcome of which was published in peer-reviewed scientific journals. This, together with global success in business, led to industry-coveting awards. Estraflex CMO and i-Sabi are the latest additions to the company’s ingredient portfolio and each promise an encouraging future. Following are key milestones of the company.


  • Founded in Newport Beach, CA.
  • Introduced BioCell Collagen™


  • In a human clinical study, BioCell Collagen™ was shown to significantly reduce subjective joint pain in 90% (80 out of 89) of the subjects.


  • Issued first patents from USPTO.


  • Issued additional patents from USPTO.


  • Presented the outcome of a human clinical trial on joint discomfort in an international conference, Experimental Biology 2004, Washington, DC.
  • In a human study, BioCell Collagen™ was shown to remarkably enhance the bioavailability of hyaluronic acid in the blood.  
  • Issued additional patents from USPTO.


  • BioCell Collagen™ was shown to inhibit hyaluronidase that degraded hyaluronic acid.


  • Introduced a novel innovative ingredient, i-Sabi, derived from Wasabia japonica known for a wide-range of health-promoting properties via Nrf-2 activation.


  • Study confirming oral safety of BioCell Collagen™ was published in Food and Chemical Toxicology (http://www.ncbi.nlm.nih.gov/pubmed/17030382).
  • An in vitro study on i-Sabi showed its potent antioxidant and healthy immune support properties.


  • BioCell Collagen™ received a Canadian patent for its method and use.


  • BioCell Collagen™ secured GRAS (Generally Regarded As Safe) affirmation.
  • A human clinical trial enrolling eighty subjects confirmed earlier results demonstrating the safety and efficacy of BioCell Collagen™ in supporting joint health.


  • BioCell Collagen™ received the Frost and Sullivan’s North American Customer Value Enhancement of the Year Award in Bone and Joint Health Ingredients


  • Published a confirmatory human clinical study on joint discomfort in the Journal of Agricultural Food and Chemistry (http://www.ncbi.nlm.nih.gov/pubmed/22486722).
  • Published a human skin study on healthy aging in the Clinical Investigation of Aging (http://www.ncbi.nlm.nih.gov/pubmed/22956862).
  • BioCell Collagen™ received a new product license from the Natural Health Product Directorate of the Health Canada and became the first hydrolyzed collagen-containing ingredient approved for use to improve both joint health and skin beauty.
  • BioCell Collagen™ CG received Frost & Sullivan’s 2012 North American Collagen Peptide in Personal Care New Product Innovation Award.
  • BioCell Collagen™, a Finalist of the NBT Award for the Most Innovative Ingredient



  • The new findings highlight the effect of BioCell Collagen on tendon and ligament connective tissue recovery in healthy subjects following intense resistance training exercise. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271657/)
  • BioCell Technology LLC becomes a voting Member of the Council for Responsible Nutrition (CRN)



  • BioCell Collagen awarded Halal status in US and Germany