BioCell Collagen

BioCell Collagen® - Feed Your Skin & Joints®

BioCell Collagen® is a branded dietary ingredient composed of a unique matrix of hydrolyzed collagen type II, chondroitin sulfate and hyaluronic acid clinically shown to promote connective tissue health of the joints and skin. Various studies including seven human clinical trials support the safety, efficacy, bioavailability of BioCell Collagen. BioCell Collagen is self-affirmed GRAS (Generally Regarded As Safe). BioCell Collagen is non-GMO and free of gluten, soy, shellfish, fish, egg, milk, peanuts and sugar. BioCell Collagen is made exclusively in the USA and Europe.

Joint Health and Sports Nutrition

Clinically shown to:

  • Improve joint comfort and mobility*
  • Support post-exercise recovery*;

Skin Beauty-From-Within

Clinically shown to:

  • Reduce facial fine lines and wrinkles*
  • Reduce facial skin dryness/scaling*
  • Increase facial collagen content in the dermis and blood microcirculation*


  • BioCell Collagen (fine powder), for use in tablets, capsules and soft gels.
  • BioCell Collagen FG (food grade), for use in chewable and functional food applications.
  • BioCell Collagen CG (Cosmetic Grade), specially formulated for use in topical applications.


BioCell Collagen is used in dietary supplements for the promotion of skin and joint health. , connective tissue, tendon and ligament health. The safety and efficacy of BioCell Collagen has been demonstrated in multiple human studies over the decade.


What is in BioCell Collagen?

BioCell Collagen® is a science based, clinically tested dietary ingredient that promotes active joints, youthful looking skin, and healthy connective tissues. Unlike other collagen and hyaluronic acid ingredients on the market, BioCell Collagen contains a patented composition of naturally occurring hydrolyzed collagen type II (60%), chondroitin sulfate (20%), and hyaluronic acid (10%) in a highly absorbable matrix form (NOT A BLEND) that has been the subject of numerous human clinical trials including safety, efficacy, and bioavailability.

BioCell Collagen® is a registered trademark of BioCell Technology, LLC. The BioCell Collagen® logo of authenticity is proudly displayed on the labels of finished products that contain BioCell Collagen®.

Is BioCell Collagen safe for human consumption?

BioCell Collagen has been safely and successfully used by millions of consumers since its introduction in the market in 1997. It was affirmed GRAS (Generally Recognized as Safe) by an independent expert safety panel following rigorous scientific review of safety and toxicology data, including various in vitro and in vivo toxicology studies. BioCell Collagen is made from hormone and antibiotic free chicken sternal cartilage under strict cGMP (current Good Manufacturing Practices) conditions in facilities located in United States and Europe. BioCell Collagen is non-GMO and free of gluten, soy, shellfish, fish, egg, milk, peanuts and sugar.

How does BioCell Collagen promote healthy aging of skin?

1. Helps rebuild the dermal matrix with highly bioavailable building blocks
Collagen, hyaluronic acid (HA), and chondroitin sulfate are essential for the healthy structure and function of the skin dermis. As one ages, the amounts of these components decrease which leads to the disorganization or collapse of the dermal matrix. Clinical studies demonstrate that supplementing with BioCell Collagen promotes skin beauty from within. Collagen provides tensile strength of the dermal matrix in which ground substances such as hyaluronic acid are interweaved. Additionally, increasing the density of dermal fibroblasts, which are responsible for biosynthesis of structural components for the dermal network, can also contribute to youthful appearance of skin.

2. Enhances skin hydration, turgidity, and inhibition of hyaluronidase
Maintaining a proper amount of HA is critical for healthy skin structure and turgidity because HA is responsible for holding water in the skin dermis. HA and collagen decrease with age, resulting in dermal dehydration, skin-sagging, and wrinkle formation. BioCell Collagen supplies highly bioavailable HA to attenuate the effect of the loss caused by natural deterioration or photo-aging. Human subjects who took a daily dose of BioCell Collagen saw HA levels increase 60-fold in their blood during 28 days of the study period.

HA levels are maintained by the coordinated action of HA syntheses and hyaluronidases. Hyaluronidase degrades HA in response to a number of normal or pathological stimuli including aging and inflammation. BioCell Collagen has been shown to inhibit hyaluronidase. Thus, BioCell Collagen can tackle an important molecular player responsible for aging-associated dehydration while replenishing the loss of the various essential structural components of the skin dermis.
In 2011, BioCell Technology performed a ground-breaking human skin study and demonstrated that daily ingestion of BioCell Collagen for 12 weeks led to a significant reduction of facial lines and wrinkles together with enhancement of hydration and stimulation of collagen biosynthesis likely from dermal fibroblasts. It also led to an increase in hemoglobin in the facial skin tissue suggesting enhanced microcirculation of blood in the dermis. The majority of the study participants experienced improved skin texture as well as enhanced moisture and reduced scaling in their face. The study outcome was published in The Clinical Interventions in Aging (2012).

What is BioCell Collagen made from?

BioCell Collagen is made from hormone and antibiotic free chicken sternal cartilage because it is a rich source of collagen type II, hyaluronic acid, and chondroitin sulfate and closely mirrors the composition of human articular cartilage. Cartilage is a very clean source because it is free from blood supply; it does not contain blood and lymphatic vessels or capillaries like other animal parts which collagen type I & III ingredients are made from. This is important because a lot of diseases, bacteria, viruses, steroids, antibiotics are bloodborne or carried through the blood supply. Collagen type I & III are derived from hides, bones and skin of animals (beef, chicken, pork, marine) as opposed to type II, which is rarer because it is predominantly found in cartilage where it naturally coexists with hyaluronic acid and chondroitin sulfate in a blood free environment.
BioCell Collagen is made via a patented manufacturing procedure that subjects the chicken sternal cartilage through various processes including filtration, purification, concentration, hydrolysis, and sterilization to ensure consistent quality and safety. Our patented process remarkably removes impurities and reduces the size of all its molecules, making them highly absorbable and fast-acting. This composition and synergy among the three molecules is unique to BioCell Collagen and cannot be found in any other collagen ingredients or blends. BioCell Collagen is affirmed GRAS (Generally Recognized as Safe) and is non-GMO and gluten free. Collagen does not naturally exist in plants.

What is the effective clinical dose of BioCell Collagen?

The dosages of BioCell Collagen taken in our clinical trials were 1 g (1000 mg) per day for skin health and 2 g (2000 mg) per day for joint and skin health benefits.


BioCell Collagen™, variously in name and/or design, are trademarks of BioCell Technology, LLC, and are registered in the United States and other jurisdictions. (Pat.: