BioCell Collagen

Feed your skin & joints™

BioCell Collagen® is a multifaceted healthy aging dietary ingredient that contains a patented composition of naturally occurring hydrolyzed collagen type II (60%), chondroitin sulfate (20%), and hyaluronic acid (10%) in a highly absorbable matrix form (NOT A BLEND) that has been the subject of numerous human clinical trials including safety, efficacy, and bioavailability.  

Joint Support

  • Provides nutrients essential for maintaining cartilage, tendon and ligament connective tissue health. 
  • Clinically shown to improve joint comfort, mobility and quality of life. 
  • Clinically shown to impact key biochemical markers of connective and skeletal muscle tissue damage and enhance stress resilience following intense resistance exercise. 
  • The bioavailable hyaluronic acid and chondroitin sulfate in BioCell Collagen promotes joint cushioning and lubrication.
  • May help renew cartilage by stimulating chondrocytes (cartilage producing cells). 

Beauty-From-Within Skin Support

  • Clinically shown to reduce fine lines and wrinkles by counteracting both natural and photoaging processes.
  • Clinically shown to reduce skin dryness/scaling via HA-mediated increase in skin hydration leading to enhanced turgidity and suppleness.
  • Clinically shown to increase collagen content in the dermis by supporting the tensile strength of skin.
  • Clinically shown to increase blood microcirculation of facial skin.
  • Promotes maintenance and healthy aging of skin.
  • Supports healthy hair and nails.


  • BioCell Collagen (fine powder), for use in capsules and soft gels.
  • BioCell Collagen FG (food grade), for use in chewables and functional food applications.
  • BioCell Collagen CG-WS (cosmetic grade), specially formulated for use in topical applications.


BioCell Collagen was designed to be used daily for the promotion of skin, joint, connective tissue, tendon and ligament health. The safety and efficacy of BioCell Collagen has been demonstrated in multiple human studies over the decade. 


What is in BioCell Collagen?

BioCell Collagen® is a science based, clinically tested dietary ingredient that promotes active joints, youthful looking skin, and healthy connective tissues. Unlike other collagen and hyaluronic acid ingredients on the market, BioCell Collagen contains a patented composition of naturally occurring hydrolyzed collagen type II (60%), chondroitin sulfate (20%), and hyaluronic acid (10%) in a highly absorbable matrix form (NOT A BLEND) that has been the subject of numerous human clinical trials including safety, efficacy, and bioavailability.

BioCell Collagen® is a registered trademark of BioCell Technology, LLC. The BioCell Collagen® logo of authenticity is proudly displayed on the labels of finished products that contain BioCell Collagen®.

Is BioCell Collagen safe for human consumption?

BioCell Collagen has been safely and successfully used by millions of consumers since its introduction in the market in 1997. It was affirmed GRAS (Generally Recognized as Safe) by an independent expert safety panel following rigorous scientific review of safety and toxicology data, including various in vitro and in vivo toxicology studies. BioCell Collagen is made from hormone and antibiotic free chicken sternal cartilage under strict cGMP (current Good Manufacturing Practices) conditions in facilities located in United States and Europe. BioCell Collagen is non-GMO and free of gluten, soy, shellfish, fish, egg, milk, peanuts and sugar.

How does BioCell Collagen provide dual benefits for joints and skin?

Multiple human clinical studies substantiate the use of BioCell Collagen as a daily supplement for promoting joint and skin health. The unique and clinically-proven dual benefits are realized by targeting connective tissue which is the glue like network that connects bodily tissues and organs. These connective tissues, although residing at different physiological locations, consist of a similar nature of molecules including collagen and glycosaminoglycans (GAGs) such as hyaluronic acid and chondroitin sulfate. Additionally, studies suggest that BioCell Collagen can stimulate chondrocytes in the cartilage and dermal fibroblasts in skin dermis that synthesize collagen and GAGs, providing a potential regenerative mechanism. BioCell Collagen provides comprehensive, highly bioavailable nutrients essential for maintaining cartilage, tendon and ligament connective tissue health.

How can BioCell Collagen support joint health?

BioCell Collagen provides a unique and comprehensive solution to joint health. It does so by:

1. Replenishing essential components of cartilage matrix and lubricating synovial fluid

The molecular composition of BioCell Collagen mirrors that of the articular cartilage where collagen type II, hyaluronic acid (HA) and chondroitin sulfate are the three major components. HA is also a constituent of the synovial fluid, the lubricating fluid in our joints. Unfortunately, the amount of these components and the integrity of the cartilage matrix decrease due to joint degeneration and the natural processes of aging. BioCell Collagen is a highly bioavailable source of hydrolyzed collagen type II, chondroitin sulfate and HA. Double-blind, placebo-controlled clinical trials demonstrate its safety and efficacy in promoting joint comfort and mobility.

2. Deposition of hydrolyzed collagen peptides in target tissues such as cartilage and potential cartilage regeneration

Scientific evidence suggests that BioCell Collagen is absorbed intestinally and accumulated in cartilage. Moreover, hydrolyzed collagen type II, unlike unhydrolyzed (undenatured or native) collagen type II, has been shown to stimulate novel biosynthesis of type II collagen from chondrocytes, cartilage-producing cells. The data suggests a very intriguing hypothesis that hydrolyzed collagen type II in BioCell Collagen may directly stimulate the resident cells in the cartilage to produce its matrix components, thereby promoting joint structure and function.

How does BioCell Collagen promote healthy aging of skin?

1. Helps rebuild the dermal matrix with highly bioavailable building blocks
Collagen, hyaluronic acid (HA), and chondroitin sulfate are essential for the healthy structure and function of the skin dermis. As one ages, the amounts of these components decrease which leads to the disorganization or collapse of the dermal matrix. Clinical studies demonstrate that supplementing with BioCell Collagen promotes skin beauty from within. Collagen provides tensile strength of the dermal matrix in which ground substances such as hyaluronic acid are interweaved. Additionally, increasing the density of dermal fibroblasts, which are responsible for biosynthesis of structural components for the dermal network, can also contribute to youthful appearance of skin.

2. Enhances skin hydration, turgidity, and inhibition of hyaluronidase
Maintaining a proper amount of HA is critical for healthy skin structure and turgidity because HA is responsible for holding water in the skin dermis. HA and collagen decrease with age, resulting in dermal dehydration, skin-sagging, and wrinkle formation. BioCell Collagen supplies highly bioavailable HA to attenuate the effect of the loss caused by natural deterioration or photo-aging. Human subjects who took a daily dose of BioCell Collagen saw HA levels increase 60-fold in their blood during 28 days of the study period.

HA levels are maintained by the coordinated action of HA syntheses and hyaluronidases. Hyaluronidase degrades HA in response to a number of normal or pathological stimuli including aging and inflammation. BioCell Collagen has been shown to inhibit hyaluronidase. Thus, BioCell Collagen can tackle an important molecular player responsible for aging-associated dehydration while replenishing the loss of the various essential structural components of the skin dermis.
In 2011, BioCell Technology performed a ground-breaking human skin study and demonstrated that daily ingestion of BioCell Collagen for 12 weeks led to a significant reduction of facial lines and wrinkles together with enhancement of hydration and stimulation of collagen biosynthesis likely from dermal fibroblasts. It also led to an increase in hemoglobin in the facial skin tissue suggesting enhanced microcirculation of blood in the dermis. The majority of the study participants experienced improved skin texture as well as enhanced moisture and reduced scaling in their face. The study outcome was published in The Clinical Interventions in Aging (2012).

Is BioCell Collagen similar to Glucosamine?

No, glucosamine offers only a partial approach to joint health, while BioCell Collagen is a multi-dimensional ingredient that supports both joint and skin health. BioCell Collagen offers a more complete approach to joint health by providing the body with cartilage nutrients such as collagen type II (most abundant protein in cartilage), hyaluronic acid (major component of synovial joint lubrication fluid) and chondroitin sulfate (shock absorbing molecule), in a patented, molecularly optimized form. BioCell Collagen with its uniquely differentiated properties provides broader nutritional support.

What is BioCell Collagen made from?

BioCell Collagen is made from hormone and antibiotic free chicken sternal cartilage because it is a rich source of collagen type II, hyaluronic acid, and chondroitin sulfate and closely mirrors the composition of human articular cartilage. Cartilage is a very clean source because it is free from blood supply; it does not contain blood and lymphatic vessels or capillaries like other animal parts which collagen type I & III ingredients are made from. This is important because a lot of diseases, bacteria, viruses, steroids, antibiotics are bloodborne or carried through the blood supply. Collagen type I & III are derived from hides, bones and skin of animals (beef, chicken, pork, marine) as opposed to type II, which is rarer because it is predominantly found in cartilage where it naturally coexists with hyaluronic acid and chondroitin sulfate in a blood free environment.
BioCell Collagen is made via a patented manufacturing procedure that subjects the chicken sternal cartilage through various processes including filtration, purification, concentration, hydrolysis, and sterilization to ensure consistent quality and safety. Our patented process remarkably removes impurities and reduces the size of all its molecules, making them highly absorbable and fast-acting. This composition and synergy among the three molecules is unique to BioCell Collagen and cannot be found in any other collagen ingredients or blends. BioCell Collagen is affirmed GRAS (Generally Recognized as Safe) and is non-GMO and gluten free. Collagen does not naturally exist in plants.

What is the effective clinical dose of BioCell Collagen?

The dosages of BioCell Collagen taken in our clinical trials were 1 g (1000 mg) per day for skin health and 2 g (2000 mg) per day for joint and skin health benefits.

BioCell Collagen™, variously in name and/or design, are trademarks of BioCell Technology, LLC, and are registered in the United States and other jurisdictions. (Pat.: