i-Sabi Wasabia japonica
A wide spectrum of biological properties implicated in various health benefits as follows.
HEALTHY IMMUNE SUPPORT
Potent specific suppression of COX-2, leaving COX-1 intact
Potent liver detoxification via induction of a master switch, Nrf-2, for cytoprotective genes
Protecting cells against oxidative damage
Enhancing neurite growth
Wasabi’s key active compound, 6-HITC (methylsulfinylhexyl isothiocyanate) stimulates Nrf-2, a master switch to induce genes that are involved in the protection of cells against various stresses and damage. Additionally, i-Sabi containing min 15,000 ppm 6-HITC suppresses Cox-2 specifically, an enzyme responsible for chronic inflammation, providing a healthy immune support.
- i-SabiTM can be formulated in various forms including capsules, tablets, and soft-gels.
- Broad applications of i-SabiTM, depending on whether it is used as a single supplement or a novel ingredient in a combination formula.
- Cells throughout our body continue to receive various types of stress from oxidation, inflammation, and toxic substances. i-Sabi can help everybody so that he or she can maintain both liver and immune health by eliciting a healthy physiological responses
i-Sabi is a freezed-dried powder derived from the rhizome of wasabi plants and contains a high amount of 6-HITC and other inherent compounds such as indole-3-carbinol.
Yes, as wasabi has been traditionally used as the famous sushi condiment. There have been no adverse events reported in studies in animal models as well.
i-Sabi is manufactured via a proprietary process so that the glucosinolate-myrosinase system in the plants generates a highest amount of 6-HITC (min 15, 000 ppm).
They include liver detoxification and healthy inflammatory support via potent suppression of chronic Cox-2 expression while leaving Cox-1 intact. It also provides antioxidant and brain health support. Its mechanism of action has been identified as Nrf-2 induction being the key upstream event.
Cells are under constant attack from internal and external stresses caused by oxygen, inflammations, smoking, grilled meat, and sunlight, which generate highly reactive substances such as radicals. Subsequent damages to cells may underlie a number of chronic health conditions.
Cells in our body have a stress-response system to protect themselves against the reactive substances by a battery of enzymes and radical scavengers. The major switch that turns on the protection system is Nrf-2. Studies have shown that 6-HITC richly contained in i-Sabi stimulates Nrf-2 which induces various cytoprotective enzymes downstream in the signaling cascade. This Nrf-2 system helps cells effectively cope with oxidative, inflammatory, and xenobiotic stresses.
Wasabi and broccoli belong to the same family and contain specific ITCs. Brocolli’s ITC is called sulforaphane which also has a spectrum of biological properties similar to those of 6-HITC. However, 6-HITC appears to be more potent in its activity such as liver detoxification because the levels of induction of GST and NQO-1 enzymes were higher.
The recommended dose is 200 mg 1 to 3 times a day. The dose is determined in studies performed using animal models.