i-Sabi Wasabia japonica
A wide spectrum of biological properties implicated in various health benefits as follows.
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HEALTHY IMMUNE SUPPORT
Potent specific suppression of COX-2, leaving COX-1 intact -
LIVER HEALTH
Potent liver detoxification via induction of a master switch, Nrf-2, for cytoprotective genes -
ANTIOXIDANT
Protecting cells against oxidative damage -
BRAIN HEALTH
Enhancing neurite growth
Wasabi’s key active compound, 6-HITC (methylsulfinylhexyl isothiocyanate) stimulates Nrf-2, a master switch to induce genes that are involved in the protection of cells against various stresses and damage. Additionally, i-Sabi containing min 15,000 ppm 6-HITC suppresses Cox-2 specifically, an enzyme responsible for chronic inflammation, providing a healthy immune support.
Applications
- i-SabiTM can be formulated in various forms including capsules, tablets, and soft-gels.
- Broad applications of i-SabiTM, depending on whether it is used as a single supplement or a novel ingredient in a combination formula.
Usage
- Cells throughout our body continue to receive various types of stress from oxidation, inflammation, and toxic substances. i-Sabi can help everybody so that he or she can maintain both liver and immune health by eliciting a healthy physiological responses
FAQs
What is i-Sabi?
i-Sabi is a freezed-dried powder derived from the rhizome of wasabi plants and contains a high amount of 6-HITC and other inherent compounds such as indole-3-carbinol.
Is i-Sabi safe for human consumption?
Yes, as wasabi has been traditionally used as the famous sushi condiment. There have been no adverse events reported in studies in animal models as well.
How much 6-HITC does i-Sabi have?
i-Sabi is manufactured via a proprietary process so that the glucosinolate-myrosinase system in the plants generates a highest amount of 6-HITC (min 15, 000 ppm).
What are the major health benefits and how?
They include liver detoxification and healthy inflammatory support via potent suppression of chronic Cox-2 expression while leaving Cox-1 intact. It also provides antioxidant and brain health support. Its mechanism of action has been identified as Nrf-2 induction being the key upstream event.
Why is Nrf-2 called a master switch to wellness?
Cells are under constant attack from internal and external stresses caused by oxygen, inflammations, smoking, grilled meat, and sunlight, which generate highly reactive substances such as radicals. Subsequent damages to cells may underlie a number of chronic health conditions.
Cells in our body have a stress-response system to protect themselves against the reactive substances by a battery of enzymes and radical scavengers. The major switch that turns on the protection system is Nrf-2. Studies have shown that 6-HITC richly contained in i-Sabi stimulates Nrf-2 which induces various cytoprotective enzymes downstream in the signaling cascade. This Nrf-2 system helps cells effectively cope with oxidative, inflammatory, and xenobiotic stresses.
How is i-Sabi different from broccoli ingredient?
Wasabi and broccoli belong to the same family and contain specific ITCs. Brocolli’s ITC is called sulforaphane which also has a spectrum of biological properties similar to those of 6-HITC. However, 6-HITC appears to be more potent in its activity such as liver detoxification because the levels of induction of GST and NQO-1 enzymes were higher.
What is an effective daily dose of i-Sabi?
The recommended dose is 200 mg 1 to 3 times a day. The dose is determined in studies performed using animal models.
research data
Wasabia japonica (wasabi) has a variety of bioactive compounds, and 6-HITC is the most potent and active components and the primary reason for a multitude of physiological effects of wasabi.
6-HITC (6-methylsulfinylhexyl isothiocyanates)
A key bioactive compound and responsible for sharp taste of wasabi plants. 6-HITC is generated from glucosinolates by the action of myrosinase contained in intact plants which becomes activated when the plant is harvested or attacked by microorganisms.
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Healthy immune support by specific Cox-2 suppression, leaving Cox-1 intact
i-Sabi provides a potent and selective Cox-2 suppression while leaving Cox-1 intact. Since Cox-2 does not play a role in the normal function of the stomach, i-Sabi will not present the risk of injuring the stomach but is effective in alleviating a chronic inflammatory stress throughout our body.
Cox-1, Cox-2, and NSAIDs side-effects
Cox-1 (cyclooxygenase-1) is an essential enzyme constitutively present in various areas of the body, including inflammatory sites and the stomach. Cox-1 in the stomach generates chemical messengers called prostaglandins that ensure the natural mucus lining to protect the inner stomach.
Common anti-inflammatory drugs, like aspirin or ibuprofen, block Cox-1 and the other Cox enzyme, Cox-
2, which is induced by inflammatory stimuli. With these anti-inflammatory medications, inflammation is inhibited by Cox-2 suppression, but the protective mucus lining of the stomach is also reduced because Cox-1 is blocked. This could cause serious side effects such as stomach upset, ulceration, and bleeding from the stomach and intestines.
Although producing the same inflammatory chemical messenger, Cox-2 expression is induced only in inflammatory areas, but not in the stomach. Temporary Cox-2 induction is necessary to remove inflammatory stimuli such as microbial invasion. However, sustained Cox-2 expression contributes to many serious chronic health conditions. Thus, Cox-2 induction needs to be tightly regulated by the immune system.
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Liver detoxification
While playing a major role in various metabolisms including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, the liver is the primary detoxification site in our body. Many enzymes and pathways are involved in drug metabolism, and can be divided into Phase I and Phase II reactions.Wasabi containing 6-HITC has a potent liver detoxification activity including the induction of GST (glutathione S transferase) and NQO-1 (NAD(P)H quinone oxidoreductase-1), HO-1 (heme oxygenase-1) via stimulation of Nrf-2. GST can remove the toxicity of ingested foreign substances (xenobiotics) and its subsequent contribution to inflammation and cell transformation while the other cytoprotective enzymes provide protection against cellular stress.
Master role of Nrf-2 in cell protection against oxidation and inflammation
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i-Sabi protects red blood cells against oxidative stress
This data demonstrated the permeability of active compounds contained in i-Sabi through the cell membrane of red blood cells. Once inside, i-Sabi-derived compounds effectively reduce oxidative stress, thereby providing the protection of macromolecules such as DNA, lipid, and proteins.
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Brain health by enhancing neurite growth (neuritogenesis)
A neurite refers to any projection from the cell body of a neuron. This structural differentiation is essential for the neuronal signal transmission via NGF, a neurotrophin, which binding and activation of its receptor, TrkA (neurotrophic tyrosine kinase receptor, type 1), is required for neuronal survival and differentiation.Enhancing neurite growth stimulated by 6-HITC and delineation of its molecular mechanism involving the protein tyrosine phosphatase implies the utility of i-Sabi as a beneficial dietary ingredient for aging-related neurologic problems such as memory loss.
