Feed your skin & joints™
BioCell Collagen® is a multifaceted healthy aging dietary ingredient that contains a patented composition of naturally occurring hydrolyzed collagen type II (60%), chondroitin sulfate (20%), and hyaluronic acid (10%) in a highly absorbable matrix form (NOT A BLEND) that has been the subject of numerous human clinical trials including safety, efficacy, and bioavailability.
- Provides nutrients essential for maintaining cartilage, tendon and ligament connective tissue health.
- Clinically shown to improve joint comfort, mobility and quality of life.
- Clinically shown to impact key biochemical markers of connective and skeletal muscle tissue damage and enhance stress resilience following intense resistance exercise.
- The bioavailable hyaluronic acid and chondroitin sulfate in BioCell Collagen promotes joint cushioning and lubrication.
- May help renew cartilage by stimulating chondrocytes (cartilage producing cells).
Beauty-From-Within Skin Support
- Clinically shown to reduce fine lines and wrinkles by counteracting both natural and photoaging processes.
- Clinically shown to reduce skin dryness/scaling via HA-mediated increase in skin hydration leading to enhanced turgidity and suppleness.
- Clinically shown to increase collagen content in the dermis by supporting the tensile strength of skin.
- Clinically shown to increase blood microcirculation in the face.
- Promotes maintenance and healthy aging of skin.
- Great for healthy hair and nails too.
- BioCell Collagen (fine powder), for use in capsules and soft gels.
- BioCell Collagen TG (tablet grade), for use in tablets.
- BioCell Collagen FG (food grade), for use in chewables and functional food applications.
- BioCell Collagen CG-WS (cosmetic grade), specially formulated for use in topical applications.
The safety and efficacy of BioCell Collagen in promoting active joints and younger-looking skin has been demonstrated in multiple human studies over the decade. It can be ingested by those who seek a safe, effective and comprehensive dietary ingredient.
BioCell Collagen is a multi-patented healthy aging ingredient that promotes both active joints and younger looking skin. It naturally contains hydrolyzed collagen type 2, hyaluronic acid and chondroitin sulfate, all of which are highly bioavailable due to their very low MW. Unlike other ingredients, it provides multi-dimensional molecular and biochemical support that helps the body more effectively replenish the connective tissue in targeted areas such as the joint and the skin.
BioCell Collagen II® has been awarded four United States Patents (US patent #6,025,327, #6,323,319, #6,780,841, and #7,091,180) for the manufacturing and various uses thereof. Other US and foreign patents pending.
Since its introduction in 1997, BioCell Collagen has been demonstrating its safety in many different research venues. Most importantly, the five human clinical studies over the last ten years did not show any associated severe adverse events. On the other hand, various in vitro and in vivo toxicology studies provided data supporting that daily ingestion of BioCell Collagen is safe for human consumption. Thanks to the accumulated scientific evidence, BioCell Collagen acquired the self-affirmed status of GRAS (Generally Regarded As Safe) in 2010.
BioCell Collagen contains three major highly-bioavailable, biologically-active constituents: hydrolyzed collagen (primarily type II), and low molecular weight HA and chondroitin sulfate. Studies suggest that the patented process to reduce the molecular weight of collagen and the two glycosaminoglycans (GAGs) brought about various novel biological properties distinct from their undenatured, high molecular weight versions. More importantly, this hydrolysis step generates highly bioavailable building blocks essential not only for the joint cartilage matrix, but for dermal (skin) matrix because both apparently disparate tissues share macromolecular components (collagen, HA, and chondroitin sulfate) which are synthesized by the chondrocytes in the cartilage and the dermal fibroblasts in the dermis incorporating these building blocks.
BioCell Collagen provides a unique comprehensive support for joint health.
1. Replenishing essential components of cartilage matrix and lubricating synovial fluid
The synovial joint is the most common and the most active joint of the body. The composition of BioCell Collagen mirrors that of the articular cartilage of human synovial joints where collagen, HA and chondroitin sulfate are the three major components. HA plays a second role as a major lubricating agent in the synovial fluid. Unfortunately, the amount of these components and the integrity of the cartilage matrix decrease due to aging or joint degeneration. Highly bioavailable form of hydrolyzed collagen and GAGs such as HA and chondroitin sulfate helps improve joint health by replenishing the essential molecules in molecularly optimized forms. Double-blind, placebo-controlled clinical trials of BioCell Collagen demonstrated safety and efficacy in managing various joint discomforts.
2. Deposition of hydrolyzed collagen into the cartilage and cartilage regeneration
There is another molecular mechanism for joint health benefits of BioCell Collagen. There are various independent studies suggesting that orally administered hydrolyzed collagen is absorbed intestinally and accumulated in cartilage. Moreover, hydrolyzed collagen, but not undenatured collagen, has been shown to stimulate novel biosynthesis of type II collagen from the chondrocytes. These data suggests a very intriguing hypothesis that hydrolyzed collagen in BioCell Collagen may directly stimulate the resident cells in the cartilage to produce its matrix components. This biochemical stimulation of the chondrocytes would help rebuild the cartilage, thereby normalizing structure and function of the joint.
1. Rebuilding dermal network with highly bioavailable building blocks
As discussed above, collagen, HA, and chondroitin sulfate are also essential for the healthy structure and function of the skin dermis. As one ages, the amounts of these components decrease which leads to the disorganization or collapse of the dermal matrix. Supplementing with highly bioavailable building blocks for these molecules may effectively improve skin beauty from within. Hydrolyzed collagen has been shown to support tensile collagen fibrillar network into which ground substances such as hyaluronic acid are interweaved. Additionally, increasing the density of dermal fibroblasts which are responsible for biosynthesis of structural components for the dermal network can also contributes to youthful appearance of skin.
2. Enhanced skin hydration and turgidity and inhibition of hyaluronidase
Maintaining a proper amount of HA is critical for healthy skin structure and turgidity because HA is responsible for retaining water in the skin dermis. However, its integrity and amount decreases in aging skin, resulting in dermal dehydration, skin-sagging, and wrinkle formation. BioCell Collagen supplies highly bioavailable HA to attenuate the effect of its loss caused by natural or photo-aging. Human subjects who took the daily dose of BioCell Collagen saw HA levels increase 60-fold in their blood during 28 days of the study period.
BioCell Collagen provides an additional support of HA. HA levels are maintained by the coordinated action of HA syntheses and hyaluronidases. Hyaluronidase degrades HA in response to a number of normal or pathological stimuli including aging and inflammation. BioCell Collagen has been shown to inhibit hyaluronidase. Thus, BioCell Collagen can tackle an important molecular player responsible for aging-associated dehydration while replenishing the loss of the various essential structural components from skin dermis.
3. Protecting UV-mediated skin damages
A recent independent study showed that ingestion of hydrolyzed collagen could protect UV-mediated skin damages such as, dehydration, and type I collagen loss. This suggests that collagen peptides contained in BioCell Collagen would provide similar benefits which are further supported by maintaining healthy levels of HA.
No. BioCell Collagen has not been characterized for glucosamine. Although it contains chondroitin sulfate, the molecular nature and bioavailability is quite different from those of chondroitin sulfate derived from other sources.
Glucosamine and/or chondroitin sulfate has been a most popular dietary ingredient in joint health category. Recently, however, more rigorous clinical trials and comprehensive analysis of the old datasets continue to show the lack of clinical benefits from glucosamine ingestion. In particular, a review (2010) analyzed all the available datasets until 2009 from ten well-controlled clinical trials (total 3803 subjects) on glucosamine and/or chondroitin sulfate and concluded as follows (http://www.ncbi.nlm.nih.gov/pubmed/20847017);
“Compared with placebo, glucosamine, chondroitin, and their combination do not reduce joint pain or have an impact on narrowing of joint space. Health authorities and health insurers should not cover the costs of these preparations, and new prescriptions to patients who have not received treatment should be discouraged”
Considering the composition of the cartilage and joint in general, supplementation with glucosamine and/or chondroitin sulfate only appears a partial and ineffective approach to complex degenerative joint conditions. This GAG sources would not support the collagen component which assumes about 70% of the cartilage structure.
How soon an individual may get intended joint or skin health benefits should vary. However, clinical studies on BioCell Collagen and anecdotal evidence support that consumers can start to observe the results in several weeks although they sometimes notice a difference earlier.
The dosages of BioCell Collagen taken in our clinical trials were 1 g (1000 mg) per day for skin health and 2 g (2000 mg) per day for joint and skin health benefits.